Biophysical study of resin acid effects on phospholipid membrane structure and properties

DSpace Repository

Biophysical study of resin acid effects on phospholipid membrane structure and properties

Show full item record

Files for download

Find Full text There are no files associated with this item.

Facebook

Simple item record

Publication Article, peer reviewed scientific
Title Biophysical study of resin acid effects on phospholipid membrane structure and properties
Author(s) Jagalski, Vivien ; Barker, Robert ; Topgaard, Daniel ; Gunther-Pomorski, Thomas ; Hamberger, Bjorn ; Cardenas, Marité
Date 2016
English abstract
Hydrophobic resin acids (RAs) are synthesized by conifer trees as part of their defense mechanisms. One of the functions of RAs in plant defense is suggested to be the perturbation of the cellular membrane. However, there is a vast diversity of chemical structures within this class of molecules, and there are no clear correlations to the molecular mechanisms behind the RA's toxicity. In this study we unravel the molecular interactions of the three closely related RAs dehydroabietic acid, neoabietic acid, and the synthetic analogue dichlorodehydroabietic acid with dipalmitoylphosphatidylcholine (DPPC) model membranes and the polar lipid extract of soybeans. The complementarity of the biophysical techniques used (NMR, DLS, NR, DSC, Cryo-TEM) allowed correlating changes at the vesicle level with changes at the molecular level and the co-localization of RAs within DPPC monolayer. Effects on DPPC membranes are correlated with the physical chemical properties of the RA and their toxicity.
DOI http://dx.doi.org/10.1016/j.bbamem.2016.08.008 (link to publisher's fulltext.)
Publisher Elsevier
Host/Issue Biochimica et Biophysica Acta : Biomembranes;11
Volume 1858
ISSN 0005-2736
Pages 2827-2838
Language eng (iso)
Subject(s) Membranes
Sciences
Research Subject Categories::NATURAL SCIENCES
Handle http://hdl.handle.net/2043/21187 (link to this page)

This item appears in the following Collection(s)

Show full item record

Search


Browse

My Account

Statistics