Magnesium release from mesoporous carriers on endosseus implants does not influence bone maturation at 6 weeks in rabbit bone

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Magnesium release from mesoporous carriers on endosseus implants does not influence bone maturation at 6 weeks in rabbit bone

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Publication Article, peer reviewed scientific
Title Magnesium release from mesoporous carriers on endosseus implants does not influence bone maturation at 6 weeks in rabbit bone
Author(s) Galli, Silvia ; Andersson, Martin ; Jinno, Yohei ; Karlsson, Johan ; He, Wenxiao ; Xue, Ying ; Mustafa, Kamal ; Wennerberg, Ann ; Jimbo, Ryo
Date 2016
English abstract
Objectives: The release of magnesium ions (Mg21) from titanium surfaces has been shown to boost the initial biological response of peri-implant bone and to increase the biomechanical strength of osseointegration. The objective of the present paper was to investigate if the initial improve- ment in osseointegration would influence the bone remodel- ing also during the maturation stage of bone healing. Methods: Titanium implants were coated with mesoporous titania layers and either loaded with Mg21 (test group) or left untreated (control group). The implants were inserted in the tibiae of 10 New Zealand White rabbits. Osseointegration was assessed after 6 weeks by means of biomechanical test- ing (RTQ), non-decalcified histology and histomorphometry (BIC%, BA%, NBA%). The expression of genes involved in the bone formation and remodeling was quantified using qPCR. Results: Mg21 releasing mesoporous titania coatings showed, on average, higher removal torques and histomorphometrical outcomes (RTQ: 17.2 Ncm vs. 15 Ncm; BIC: 38.8% vs. 32.1%; BA%: 71.6% vs. 64%; NBA% 62.5% vs. 54% for the tests vs the controls); however, the differences were not statistically significant. Three osteogenic markers, osteocalcin (OC), colla- gen 1 alpha 1 (COL1A1), and alkalin phosphatase (ALPL), were respectively 2-fold, 1.53-fold, and 1.13-fold up-regulated in the control group compared to the test. The expression of COL1A1 was particularly high in both groups, while the biomarkers for remodeling and inflammation showed a low expression in both groups. Significance: The results suggested that the initial enhancement in osseointegration induced by magnesium release from mesoporous titania coatings has no detrimental effects during bone maturation.
DOI http://dx.doi.org/10.1002/jbm.b.33752 (link to publisher's fulltext.)
Publisher Wiley
Host/Issue Journal of Biomedical Materials Research B : applied biomaterials;
ISSN 1552-4981
Language eng (iso)
Subject(s) mesoporous titania
magnesium
osseointegration
bone remodeling
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/21436 (link to this page)

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