Recurrence probability for keratocystic odontogenic tumors : An analysis of 6,427 cases

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Recurrence probability for keratocystic odontogenic tumors : An analysis of 6,427 cases

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Publication Article, peer reviewed scientific
Title Recurrence probability for keratocystic odontogenic tumors : An analysis of 6,427 cases
Author Chrcanovic, Bruno ; Santiago Gomez, Ricardo
Date 2016
English abstract
Purpose. To investigate and compare the probability of recurrence of keratocystic odontogenic tumors (KCOTs) for different variables and treatment protocols. Materials and Methods. An electronic search was undertaken in April 2016 that included clinical series of KCOTs reporting recurrences. Untransformed proportions and meta-analyses were performed to estimate the probability/risk of recurrence, according to several variables. Results. A total of 94 publications were included (6,427 KCOTs, 1,464 recurrences). Probability of recurrence: all lesions, 21.1%; nevoid basal cell carcinoma syndrome, 35.4%; males, 20.3%; females, 19.3%; maxilla, 15.3%; mandible, 21.5%; unilocular, 14.7%; multilocular, 24.4%; marsupialization/decompression, 28.7%; decompression+enucleation±additional therapy, 18.6%; enucleation/curettage, 22.5%; enucleation+peripheral ostectomy, 18.6%; enucleation+Carnoy’s solution, 5.3%; enucleation+cryotherapy, 20.9%; marginal/segmental resection, 2.2%. The recurrence was not statistically significantly affected by lesion location (maxilla vs. mandible, risk ratio [RR] 0.92, P=0.32) or patient’s sex (male vs. female, RR 0.94,P=0.44), but by locularity (unilocular vs. multilocular, RR 0.67, P=0.007). Recurrence risk for surgical managements: marsupialization vs. enucleation (RR 1.65,P=0.0006), marsupialization vs. resection (RR 3.17, P=0.009), enucleation alone vs. enucleation+peripheral ostectomy (RR 1.66, P=0.05), enucleation alone vs. enucleation+Carnoy’s solution (RR 1.94, P=0.03), enucleation alone vs. enucleation+cryotherapy (RR 0.88, P=0.56). Conclusions. KCOTs have a considerable rate of recurrence, which varies significantly according to some clinical, radiographic, and histopathological features, as well as surgical management.
DOI https://doi.org/10.1016/j.jcms.2016.11.010 (link to publisher's fulltext.)
Publisher Elsevier
Host/Issue Journal of Cranio-Maxillofacial Surgery;
ISSN 1010-5182
Language eng (iso)
Subject Keratocystic odontogenic tumor
Marsupialization
Enucleation
Resection
Outcome
Meta-analysis
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/21685 Permalink to this page
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