Dopamine in plasma : a biomarker for myofascial TMD pain?

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Dopamine in plasma : a biomarker for myofascial TMD pain?

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Publication Article, peer reviewed scientific
Title Dopamine in plasma : a biomarker for myofascial TMD pain?
Author Dawson, Andreas ; Stensson, Niclas ; Ghafouri, Bijar ; Gerdle, Björn ; List, Thomas ; Svensson, Peter ; Ernberg, Malin
Date 2016
English abstract
BACKGROUND: Dopaminergic pathways could be involved in the pathophysiology of myofascial temporomandibular disorders (M-TMD). This study investigated plasma levels of dopamine and serotonin (5-HT) in patients with M-TMD and in healthy subjects. METHODS: Fifteen patients with M-TMD and 15 age- and sex-matched healthy subjects participated. The patients had received an M-TMD diagnosis according to the Research Diagnostic Criteria for TMD. Perceived mental stress, pain intensity (0-100-mm visual analogue scale), and pressure pain thresholds (PPT, kPa) over the masseter muscles were assessed; a venous blood sample was taken. RESULTS: Dopamine in plasma differed significantly between patients with M-TMD (4.98 ± 2.55 nM) and healthy controls (2.73 ± 1.24 nM; P < 0.01). No significant difference in plasma 5-HT was observed between the groups (P = 0.75). Patients reported significantly higher pain intensities (P < 0.001) and had lower PPTs (P < 0.01) compared with the healthy controls. Importantly, dopamine in plasma correlated significantly with present pain intensity (r = 0.53, n = 14, P < 0.05) and perceived mental stress (r = 0.34, n = 28, P < 0.05). CONCLUSIONS: The results suggest that peripheral dopamine might be involved in modulating peripheral pain. This finding, in addition to reports in other studies, suggests that dopaminergic pathways could be implicated in the pathophysiology of M-TMD but also in other chronic pain conditions. More research is warranted to elucidate the role of peripheral dopamine in the pathophysiology of chronic pain.
DOI https://doi.org/10.1186/s10194-016-0656-3 (link to publisher's fulltext.)
Link http://dx.doi.org/10.1186/s10194-016-0656-3 .Icon
Publisher Springer
Host/Issue The Journal of Headache and Pain;1
Volume 17
ISSN 1129-2377
Pages 65
Language eng (iso)
Subject 5-HT
Bruxism
Dopamine
Masseter muscle
Temporomandibular joint disorders
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/21972 Permalink to this page
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