Twenty years of enamel matrix derivative: the past, the present and the future

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Twenty years of enamel matrix derivative: the past, the present and the future

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Publication Article, review peer-reviewed scientific
Title Twenty years of enamel matrix derivative: the past, the present and the future
Author Miron, Richard J. ; Sculean, Anton ; Cochran, David L ; Froum, Stuart ; Zucchelli, Giovanni ; Nemcovsky, Carlos ; Donos, Nikos ; Lyngstadaas, Staale Petter ; Deschner, James ; Dard, Michel ; Stavropoulos, Andreas ; Zhang, Yufeng ; Trombelli, Leonardo ; Kasaj, Adrian ; Shirakata, Yoshinori ; Cortellini, Pierpaolo ; Tonetti, Maurizio ; Rasperini, Giulio ; Jepsen, Soren ; Bosshardt, Dieter D
Date 2016
English abstract
Background On June 5th, 2015 at Europerio 8, a group of leading experts were gathered to discuss what has now been 20years of documented evidence supporting the clinical use of enamel matrix derivative (EMD). Original experiments led by Lars Hammarstrom demonstrated that enamel matrix proteins could serve as key regenerative proteins capable of promoting periodontal regeneration including new cementum, with functionally oriented inserting new periodontal ligament fibres, and new alveolar bone formation. This pioneering work and vision by Lars Hammarstrom has paved the way to an enormous amount of publications related to its biological basis and clinical use. Twenty years later, it is clear that all these studies have greatly contributed to our understanding of how biologics can act as mediators for periodontal regeneration and have provided additional clinical means to support tissue regeneration of the periodontium. Aims This review article aims to: (1) provide the biological background necessary to understand the rational for the use of EMD for periodontal regeneration, (2) present animal and human histological evidence of periodontal regeneration following EMD application, (3) provide clinically relevant indications for the use of EMD and (4) discuss future avenues of research including key early findings leading to the development of Osteogain, a new carrier system for EMD specifically developed with better protein adsorption to bone grafting materials
DOI https://doi.org/10.1111/jcpe.12546 (link to publisher's fulltext.)
Publisher Munksgaard Forlag
Host/Issue Journal of Clinical Periodontology;8
Volume 43
ISSN 0303-6979
Pages 668-683
Language eng (iso)
Subject EMD
Emdogain
enamel matrix derivative
enamel matrix proteins;
intrabony defect
Osteogain
periodontal regeneration
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/22927 Permalink to this page
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