An Exploratory Case-Control Study on the Impact of IL-1 Gene Polymorphisms on Early Implant Failure

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An Exploratory Case-Control Study on the Impact of IL-1 Gene Polymorphisms on Early Implant Failure

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Publication Article, peer reviewed scientific
Title An Exploratory Case-Control Study on the Impact of IL-1 Gene Polymorphisms on Early Implant Failure
Author Cosyn, Jan ; Christiaens, Véronique ; Koningsveld, Vincent ; Coucke, Paul J ; De Coster, Peter ; De Paepe, Anne ; De Bruyn, Hugo
Date 2016
English abstract
Background The association between IL-1 gene polymorphisms and peri-implantitis has been well documented. However, data on the association with early implant failure are scarce. Purpose The objective of this case-control study was to explore the impact of IL-1A (-889), IL-1B (-511), and IL-1B (+3,954) gene polymorphisms on early implant failure in Caucasians Materials and Methods Between September 2004 and August 2007, 461 patients were treated with dental implants at the University Hospital in Ghent, Belgium. Fourteen subjects of this patient group who had experienced one or more early implant failures (within 6 months from implant installation) were recruited as cases. Fourteen controls, matched in terms of age, gender, and smoking habits, with only surviving implants, were selected from the same patient group. Allele and genotype analysis was performed on the basis of a blood sample by Sanger sequencing of polymerase chain reaction products containing the IL-1A (-889), IL-1B (-511), and IL-1B (+3,954) gene polymorphisms Results A significant impact of the IL-1A (-889) T allele (p=.039) and the IL-1B (+3,954) T allele (p=.003) on early implant failure was demonstrated (odds ratios=3.9 and 15.0, respectively). In addition, the genotypic distribution differed significantly between cases and controls for IL-1B (+3,954) (p=.015 ConclusionsThe IL-1B (+3,954) gene polymorphism seems to affect osseointegration. Additional case-control studies in larger patient groups are needed to confirm this observation.
DOI https://doi.org/10.1111/cid.12237 (link to publisher's fulltext.)
Publisher Wiley
Host/Issue Clinical Implant Dentistry and Related Research;2
Volume 18
ISSN 1523-0899
Pages 234-240
Language eng (iso)
Subject case-control study
implant failure
implant survival
interleukin;
osseointegration
polymorphism
survival rate
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/23047 Permalink to this page
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