Ameloblastic fibroma and ameloblastic fibrosarcoma : a systematic review

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Ameloblastic fibroma and ameloblastic fibrosarcoma : a systematic review

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Publication Article, review peer-reviewed scientific
Title Ameloblastic fibroma and ameloblastic fibrosarcoma : a systematic review
Author Chrcanovic, Bruno ; Brennan, Peter ; Rahimi, Siavash ; Santiago Gomez, Ricardo
Date 2017
English abstract
Purpose. To integrate the available data published to date on ameloblastic fibromas (AF) and ameloblastic fibrosarcomas (AFS) into a comprehensive analysis of their clinical/radiologic features. Methods. An electronic search was undertaken in July/2017. Eligibility criteria included publications having enough clinical, radiological and histological information to confirm a definite diagnosis. Results. 244 publications (279 central AF tumours, 10 peripheral AF, 103 AFS) were included. AF and AFS differed significantly with regard to the occurrence of patients’ mean age, bone expansion, cortical bone perforation and lesion size. Recurrence rates were: central AF (19.2%), peripheral AF (12.5%), AFS (all lesions, 35%), primary (de novo) AFS (28.8%), secondary AFS (occurring after an AF, 50%). Larger lesions and older patients were more often treated by surgical resections for central AF. Segmental resection resulted in the lowest rate of recurrence for most of the lesion types. AFS treated by segmental resection had a 70.5% lower probability to recur (OR 0.295; p=0.049) than marginal resection. 21.3% of the AFS-patients died due to complications related to the lesion. Conclusions. Very long follow-up is recommended for AF lesions, due to the risk of recurrence and malignant change into AFS. Segmental resection is the most recommended therapy for AFS.
DOI https://doi.org/10.1111/jop.12622 (link to publisher's fulltext.)
Link http://rdcu.be/vN0f/... (external link to publication)
Publisher Wiley
Host/Issue Journal of Oral Pathology & Medicine;
ISSN 1600-0714
Language eng (iso)
Subject Ameloblastic fibroma
Ameloblastic fibrosarcoma
Odontogenic tumors
Clinical features
Recurrence rate
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/23318 Permalink to this page
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