Reduced Gingival Fluid Flow: a Peripheral Marker of the Pharmacological Effect of Roquinimex.

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Reduced Gingival Fluid Flow: a Peripheral Marker of the Pharmacological Effect of Roquinimex.

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Publication Article, other scientific
Title Reduced Gingival Fluid Flow: a Peripheral Marker of the Pharmacological Effect of Roquinimex.
Author(s) Billstrom, A ; Lindberg, P ; Kinnby, B
Date 2003
English abstract
OBJECTIVE: Roquinimex is a drug with effects on inflammation and tumors. The pharmacological effect is not fully understood, and the molecular mechanism most characterized in vitro is an increase of plasminogen activator inhibitor type 2 (PAI-2) in human peripheral blood monocytes. The aims were to investigate peripheral pharmacological effects of roquinimex on peripheral blood monocytes and dog gingival fluid (GCF). DESIGN: Six dogs were used in a cross-over study. The amount of GCF was determined with a Periotron. The PAI-2 concentration in GCF was determined with ELISA. Monocytes were isolated from peripheral blood. RESULTS: Dogs treated with the drug had significantly lower GCF flow values and the PAI-2 concentration in GCF was higher, but no effect was seen on peripheral monocytes. CONCLUSION: Roquinimex treatment led to a consistently decreased flow rate of GCF and a higher local concentration of PAI-2 in GCF.
Host/Issue Inflammopharmacology.
Pages 11: 267-276
Language eng (iso)
Subject(s) Medicine
Handle http://hdl.handle.net/2043/3008 (link to this page)

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