Use of Swedish moist Snuff, Smoking and Alcohol Consumption in the Aetiology of Oral and Oropharyngeal Squamous Cell Carcinoma. A Population-based Case-control Study in Southern Sweden

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Use of Swedish moist Snuff, Smoking and Alcohol Consumption in the Aetiology of Oral and Oropharyngeal Squamous Cell Carcinoma. A Population-based Case-control Study in Southern Sweden

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Publication Article, other scientific
Title Use of Swedish moist Snuff, Smoking and Alcohol Consumption in the Aetiology of Oral and Oropharyngeal Squamous Cell Carcinoma. A Population-based Case-control Study in Southern Sweden
Author(s) Rosenquist, Kerstin ; Wennerberg, Johan ; Schildt, Elsy-Britt ; Bladstrom, Anna ; Hansson, Bengt Göran ; Andersson, Gunilla
Date 2005
English abstract
CONCLUSIONS: The results of this study confirm that both smoking of tobacco and alcohol consumption are risk factors for oral and oropharyngeal squamous cell carcinoma (OOSCC). The use of moist snuff had no effect on the risk of OOSCC, probably due to the low levels of tobacco-specific N-nitrosamines in Swedish moist snuff. OBJECTIVE: The aims of this population-based case-control study in southern Sweden were to establish risk estimates for cigarette and alcohol consumption and to evaluate whether Swedish moist snuff is a risk factor for OOSCC. MATERIAL AND METHODS: Between September 2000 and January 2004, 132/165 consecutive cases (80%) diagnosed with OOSCC and 320/396 matched controls (81%) were investigated. All subjects were interviewed and examined according to a standardized protocol. RESULTS: Individuals who drank > or =350 g of alcohol/week showed an increased risk of OOSCC (OR 2.6; 95% CI 1.3-5.4). Total lifetime consumption of tobacco for smoking (>250 kg) had a dose-response effect on the risk of OOSCC (OR 4.7; 95% CI 2.4-9.1). We found no increased risk of OOSCC associated with the use of Swedish moist snuff (OR 1.1; 95% CI 0.5-2.5).
DOI http://dx.doi.org/10.1080/00016480510043440 (link to publisher's fulltext)
Publisher Taylor & Francis
Host/Issue Acta oto-laryngologica;9
Volume 125
ISSN 0001-6489
Pages 991-8
Language eng (iso)
Subject(s) Medicine
Research Subject Categories::MEDICINE
Handle http://hdl.handle.net/2043/3101 (link to this page)

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