Thiol-Specific and Non-Specific Interactions Between DNA and Gold Nanoparticles

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Thiol-Specific and Non-Specific Interactions Between DNA and Gold Nanoparticles

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Publication Article, peer reviewed scientific
Title Thiol-Specific and Non-Specific Interactions Between DNA and Gold Nanoparticles
Author(s) Cardenas, Marité ; Barauskas, Justas ; Schillén, Karin ; Brennan, Jennifer ; Brust, Mattias ; Nylander, Tommy
Date 2006
English abstract
The contribution of nonspecific interactions to the overall interactions of thiol-ssDNA and dsDNA macromolecules with gold nanoparticles was investigated. A systematic investigation utilizing dynamic light scattering and cryogenic transmission electron microscopy has been performed to directly measure and visualize the changes in particle size and appearance during functionalization of gold nanoparticles with thiol-ssDNA and nonthiolated dsDNA. The results show that both thiol-ssDNA and dsDNA do stabilize gold nanoparticle dispersions, but possible nonspecific interactions between the hydrophobic DNA bases and the gold surface promote interparticle interactions and cause aggregation within rather a short period of time. We also discuss the adsorption mechanisms of dsDNA and thiol-ssDNA to gold particles.
DOI http://dx.doi.org/10.1021/la0530438 (link to publisher's fulltext)
Publisher American Chemical Society
Host/Issue Langmuir
Volume 22
Pages 3294-3299
Language eng (iso)
Subject(s) DNA
Gold
Sciences
Handle http://hdl.handle.net/2043/3307 (link to this page)

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