Growth of osteoblasts on lithographically modified surfaces

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Growth of osteoblasts on lithographically modified surfaces

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Publication Article, peer reviewed scientific
Title Growth of osteoblasts on lithographically modified surfaces
Author(s) Karlsson, Lennart B. ; Gorelick, Sergey ; Rahkila, Paavo ; Sagari, A.R. Ananda ; Sajavaara, Timo ; Cheng, Sulin ; van Kan, Jeroen A. ; Whitlow, Harry J
Date 2007-07
English abstract
Here we report about preliminary investigations on developing substrates for culturing osteoblasts, the cells responsible for production of mineralised bone, by lithographically modifying the surfaces of several materials. The proton beam writing system at the National University of Singapore was used to fabricate high aspect ratio structures in PMMA, while two-dimensional low aspect ratio structures were fabricated using conventional electron beam lithography (EBL) and UV lithography (UVL) in SU-8. It was found that oxygen plasma treatment of structured SU-8 surfaces changed the surface layer and significantly improved cell attachment and proliferation. Cells grown on patterned thick PMMA exhibit a remarkable geometry-dependent behaviour.
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Publisher Elsevier B.V.
Host/Issue Nuclear Instruments and Methods in Physics Research B;1
Volume 260
ISSN 0168-583X
Pages 130-135
Language eng (iso)
Subject(s) Osteoblast
Cell growth
Proton beam writing
Surface treatment
Research Subject Categories::NATURAL SCIENCES::Physics::Nuclear physics
Research Subject Categories::MEDICINE::Morphology, cell biology, pathology::Cell biology
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