Identification of immune responses against aldehyde-modified peptide sequences in apolipoprotein B associated with cardiovascular disease

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Identification of immune responses against aldehyde-modified peptide sequences in apolipoprotein B associated with cardiovascular disease

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Publication Article, peer reviewed scientific
Title Identification of immune responses against aldehyde-modified peptide sequences in apolipoprotein B associated with cardiovascular disease
Author(s) Nordin Fredrikson, Gunilla ; Nilsson, J ; Chyu, K-Y ; Shah, PK ; Ares, Mikko PS ; Cercek, B ; Alm, Ragnar ; Berglund, G ; Hedblad, B
Date 2003
English abstract
Objective- Atherosclerosis is associated with an immune response against oxidized LDL, which modulates the progression of the disease process. Methods and Results- Using a library of polypeptides covering the complete sequence of apoB-100, the only major protein of LDL, we have identified over 100 different human antibodies reacting against aldehyde-modified apoB-100 sequences. IgM antibody titer levels decreased with age and were associated with the intima-media thickness of the carotid artery in subjects younger than 60 years. There were also inverse associations between IgM levels and oxidized LDL in plasma. In prospective clinical studies, antibody levels against several aldehyde-modified apoB-100 sites were associated with cardiovascular disease in this age group. Whether this immune response is adaptive (protective) or maladaptive (causal) in atherosclerosis requires further investigation. Conclusions- We have characterized a large number of epitopes within the apoB-100 component of oxidized LDL that provoke an immune response in humans. These findings will make it possible to study the role of immune responses against specific sites in oxidized LDL and to determine whether these immune responses influence the risk for future cardiac events.
DOI http://dx.doi.org/10.1161/01.ATV.0000067935.02679.B0 (link to publisher's fulltext)
Publisher The Assoc.
Host/Issue Arteriosclerosis, thrombosis, and vascular biology
Volume 23
ISSN 1079-5642
Pages 872-878
Language eng (iso)
Subject(s) apolipoproteins
peptide sequences
immune responses
cardiovascular diseases
atherosclerosis
Research Subject Categories::SOCIAL SCIENCES
Handle http://hdl.handle.net/2043/619 (link to this page)

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