Inhibition of atherosclerosis in apoE null mice by immunization with apo B-100 peptide sequences

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Inhibition of atherosclerosis in apoE null mice by immunization with apo B-100 peptide sequences

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Publication Article, peer reviewed scientific
Title Inhibition of atherosclerosis in apoE null mice by immunization with apo B-100 peptide sequences
Author(s) Nordin Fredrikson, Gunilla ; Nilsson, J ; Shah, PK ; Chyu, K-Y ; Dimayuga, P ; Lindholm, Maud ; Söderberg, Ingrid
Date 2003
English abstract
Objective- LDL oxidation is believed to play an important role in the development of atherosclerosis, and oxidized LDL particles have been shown to become targets for the immune system. Immunization of animals with oxidized LDL results in reduction of atherosclerosis, suggesting an atheroprotective effect of this immune response. Methods and Results- Using a polypeptide library covering the complete sequence of apoB-100, a large number of native and malondialdehyde-modified peptide sequences in apoB-100 that are recognized by antibodies in human plasma were identified. We report here that immunization with apoB-100 peptide sequences, against which high levels of IgG and IgM antibodies are present in healthy human controls, reduce atherosclerosis in apoE-null mice by about 60%. Immunizations with these peptides were also found to increase the collagen content of subvalvular lesions. Conclusions- These studies have identified peptide sequences in apoB-100 that induce immune responses, which inhibits atherosclerosis. This suggests a way of developing an immunization therapy for coronary heart disease.
DOI http://dx.doi.org/10.1161/01.ATV.0000067937.93716.DB (link to publisher's fulltext)
Publisher The Assoc.
Host/Issue Arteriosclerosis, Thrombosis, and Vascular Biology;5
Volume 23
ISSN 1079-5642
Pages 879-884
Language eng (iso)
Subject(s) apolipoproteins
peptides
mice
immunization
atherosclerosis
Research Subject Categories::SOCIAL SCIENCES
Handle http://hdl.handle.net/2043/620 (link to this page)

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