Interactions between chitosan-modified particles and mucin-coated surfaces

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Interactions between chitosan-modified particles and mucin-coated surfaces

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Publication Article, peer reviewed scientific
Title Interactions between chitosan-modified particles and mucin-coated surfaces
Author(s) Svensson, Olof ; Thuresson, Krister ; Arnebrant, Thomas
Date 2008-06-13
English abstract
Lipid-based particles (Cubosome® particles) were surface-modified by chitosan and the ratio between particles and chitosan was optimized to minimize the free chitosan concentration in the dispersion. The modified particles were characterized by electrophoretic measurements and the pH dependence of the zeta potential could be directly related to the protonation of chitosan. Interaction between the modified particles and mucin-coated silica surfaces were subsequently investigated in situ by ellipsometry to assess the mucoadhesive properties at physiologically relevant conditions. The result showed that a substantial amount of modified particles was adsorbed to mucin-coated silica surfaces at both pH 4 and pH 6, probably due to electrostatic interactions between amino groups in chitosan and negatively charged groups in mucin. Furthermore, the amount of bound particles decreased by less than 15% upon rinsing indicating relatively strong interactions. This investigation demonstrates that ellipsometry is a useful tool to study mucoadhesive properties of particles in the submicrometer range. Moreover, the novel chitosan-modified particles may be of interest for mucosal drug delivery applications.
DOI http://dx.doi.org/10.1016/j.jcis.2008.06.013 (link to publisher's fulltext)
Publisher Elsevier Inc.
Host/Issue Journal of Colloid and Interface Science;325
Volume 2
Pages 346-350
Language eng (iso)
Subject(s) mucin
chitosan
mucoadhesion
drug delivery
particle
ellipsometry
Sciences
Research Subject Categories::NATURAL SCIENCES::Chemistry::Physical chemistry
Research Subject Categories::PHARMACY::Pharmaceutical chemistry
Handle http://hdl.handle.net/2043/6476 (link to this page)

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