Plasma oxidized LDL, a predictor for acute myocardial infarction?

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Plasma oxidized LDL, a predictor for acute myocardial infarction?

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Publication Article, peer reviewed scientific
Title Plasma oxidized LDL, a predictor for acute myocardial infarction?
Author(s) Nordin Fredrikson, Gunilla ; Nilsson, J ; Berglund, G ; Hedblad, B
Date 2003
English abstract
Objectives. Oxidized LDL has been attributed a key role in the development of atherosclerosis. Previous studies have demonstrated increased plasma levels of oxidized LDL in patients with established coronary artery disease. The aim of the present study was to investigate if plasma oxidized LDL also predicts risk for development of coronary heart disease (CHD). Design. We used a nested case-control design to study the association between plasma levels of oxidized LDL and risk for development of acute myocardial infarction (AMI) and/or death by CHD. Subjects. Oxidized LDL was analysed by ELISA in cases (n = 26), controls (n = 26) and controls with LDL cholesterol >5.0 mmol L1 (n = 26). Results. Oxidized LDL correlated with total plasma and LDL cholesterol in both cases (r = 0.72, P < 0.01, r = 0.69, P < 0.01, respectively) and controls (r = 0.71, P < 0.01, r = 0.77, P < 0.01, respectively). The oxidized LDL/plasma cholesterol ratio was higher amongst cases (13.5, range 10.7-19.8) than in controls (12.6, range 9.5-15.8, P < 0.05) and hypercholesterolaemic controls (12.2, range 8.0-16.0, P < 0.01). Conclusions. These findings identify high plasma oxidized LDL/total cholesterol ratio as a possible indicator of increased risk for AMI.
DOI (link to publisher's fulltext)
Publisher Blackwell Science
Host/Issue Journal of Internal Medicine;4
Volume 253
ISSN 0954-6820
Pages 425-429
Language eng (iso)
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