Mucins MUC5B and MUC7 in minor salivary gland secretion of children and adults

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Mucins MUC5B and MUC7 in minor salivary gland secretion of children and adults

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Publication Article, peer reviewed scientific
Title Mucins MUC5B and MUC7 in minor salivary gland secretion of children and adults
Author(s) Sonesson, Mikael ; Wickström, Claes ; Kinnby, Bertil ; Ericson, Dan ; Matsson, Lars
Date 2008
English abstract
OBJECTIVE: The study was designed to investigate the relative amount of MUC5B and MUC7 in minor salivary glands in children and adults, in order to test the hypothesis that secretion of salivary mucins changes between childhood and adulthood. METHODS: Ninety individuals in the age-groups 3-year-olds, 14-year-olds, and young adults 20-25 year-olds were recruited. Sialopapers were applied on the labial and the buccal mucosa and then placed in the Periotron 8000 (Proflowtrade mark) for calculation of the amount of saliva. The assessment of MUC5B and MUC7 was carried out in an ELISA using the LUM5B-2 and the LUM7-1 antiserum, respectively. RESULTS: MUC5B and MUC7 were detected in the labial minor gland saliva in all age groups. In buccal gland saliva, only a few individuals in each age group showed detectable amounts of the mucins. In the labial area, a significantly lower level of MUC7 was noted in 3-year-olds compared with adults. CONCLUSION: The results indicate a site-dependent difference in minor gland mucin secretion and an age-related difference in the labial gland secretion of MUC7.
DOI http://dx.doi.org/10.1016/j.archoralbio.2008.01.002 (link to publisher's fulltext)
Host/Issue Archives of oral biology;6
Volume 53
ISSN 0003-9969
Pages 523-527
Language eng (iso)
Subject(s) mucin
saliva
Medicine
Research Subject Categories::MEDICINE
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/6717 (link to this page)

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