Effect of hydroxyapatite and titania nano structures on early in vivo bone response

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Effect of hydroxyapatite and titania nano structures on early in vivo bone response

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Publication Article, peer reviewed scientific
Title Effect of hydroxyapatite and titania nano structures on early in vivo bone response
Author(s) Meirelles, Luiz ; Melin, Lory ; Peltola, Timo ; Kjellin, Per ; Kangasniemi, Ilkka ; Currie, Fredrik ; Andersson, Martin ; Albrektsson, Tomas ; Wennerberg, Ann
Date 2008
English abstract
PURPOSE: Hydroxyapatite (HA) or titania nanostructures were applied on smooth titanium implant cylinders. The aim was to investigate whether nano-HA may result in enhanced osseointegration compared to nano-titania structures. MATERIALS AND METHODS: Surface topography evaluation included detailed characterization of nano-size structures present at the implant surface combined with surface roughness parameters at the micro- and nanometer level of resolution. Microstructures were removed from the surface to ensure that bone response observed was dependent only on the nanotopography and/or chemistry of the surface. Early in vivo histological analyses of the bone response (4 weeks) were investigated in a rabbit model. RESULTS: In the present study, nano-titania-coated implants showed an increased coverage area and feature density, forming a homogenous layer compared to nano-HA implants. Bone contact values of the nano-titania implants showed a tendency to have a higher percentage as compared to the nano-HA implants (p = .1). CONCLUSION: Thus, no evidence of enhanced bone formation to nano-HA-modified implants was observed compared to nano-titania-modified implants. The presence of specific nanostructures dependent on the surface modification exhibiting different size and distribution did modulate in vivo bone response.
DOI http://dx.doi.org/10.1111/j.1708-8208.2008.00089.x (link to publisher's fulltext)
Host/Issue Clinical implant dentistry and related research;4
Volume 10
ISSN 1708-8208
Pages 245-254
Language eng (iso)
Subject(s) Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/6947 (link to this page)

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