Effects of cardiac resynchronization therapy on coronary blood flow: evaluation by transthoracic Doppler echocardiography.

DSpace Repository

Effects of cardiac resynchronization therapy on coronary blood flow: evaluation by transthoracic Doppler echocardiography.

Show full item record

Files for download

Find Full text There are no files associated with this item.

Facebook

Simple item record

Publication Article, peer reviewed scientific
Title Effects of cardiac resynchronization therapy on coronary blood flow: evaluation by transthoracic Doppler echocardiography.
Author(s) Valzania, Cinzia ; Gadler, Fredrik ; Winter, Reidar ; Braunschweig, Frieder ; Brodin, Lars-Åke ; Gudmundsson, Petri ; Boriani, Giuseppe ; Eriksson, Maria J.
Date 2008-05
English abstract
BACKGROUND: Relatively limited and conflicting data are available on the effects of cardiac resynchronization therapy (CRT) on coronary blood flow (CBF). AIMS: To investigate changes in the left anterior descending coronary artery (LAD) flow under different CRT pacing modes by means of transthoracic Doppler echocardiography (TTE). METHODS: Twenty-two responders to CRT (67+/-11 years) with idiopathic dilated cardiomyopathy underwent TTE assessment of LAD flow and Tissue Velocity Imaging during 4 programming modes: intrinsic conduction (IC), right ventricular pacing (RV), simultaneous biventricular pacing (BVP), BVP with left ventricular (LV) pre-activation. RESULTS: Mean coronary flow velocity (CFV) was increased by simultaneous BVP (p=0.0063 vs. IC) and BVP with LV pre-activation (p<0.0001 vs. IC; p=0.027 vs. simultaneous BVP). Peak CFV and LAD flow velocity/time integral were highest during BVP with LV pre-activation. A reduction in septal-to-lateral delay and an increase in peak systolic velocity in the basal septum were observed during simultaneous BVP and BVP with LV pre-activation. CONCLUSIONS: In CRT responders with idiopathic dilated cardiomyopathy, an increase in LAD flow, assessed by TTE, was observed during simultaneous BVP and BVP with LV pre-activation. This was associated with an improvement in regional myocardial contraction and a decrease in intraventricular dyssynchrony.
DOI http://dx.doi.org/10.1016/j.ejheart.2008.03.011 (link to publisher's fulltext.)
Publisher Elsevier
Host/Issue European Journal of Heart Failure;5
Volume 10
Pages 514-520
Language eng (iso)
Subject(s) Cardiac resynchronization therapy
Echocardiography
Coronary blood flow
Medicine
Research Subject Categories::MEDICINE::Physiology and pharmacology::Physiology::Clinical physiology
Handle http://hdl.handle.net/2043/7380 (link to this page)

This item appears in the following Collection(s)

Show full item record

Search


Browse

My Account

Statistics