An improved method for detecting and delineating genomic regions with altered gene expression in cancer

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An improved method for detecting and delineating genomic regions with altered gene expression in cancer

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Publication Article, peer reviewed scientific
Title An improved method for detecting and delineating genomic regions with altered gene expression in cancer
Author(s) Nilsson, Björn ; Johansson, M ; Heyden, Anders ; Melander, S ; Fioretos, Thoas
Date 2008
English abstract
Genomic regions with altered gene expression are a characteristic feature of cancer cells. We present a novel method for identifying such regions in gene expression maps. This method is based on total variation (TV) minimization, a classical signal restoration technique. In systematic evaluations, we show that our method combines top-notch detection performance with an ability to delineate relevant regions without excessive over-segmentation, making it a signi¯cant advance over existing methods. Software { Rendersome { is provided.
Publisher BioMed Central
Host/Issue Genome Biology;13
Volume 9
Language eng (iso)
Subject(s) bioinformatics
genome studies
Medicine
Research Subject Categories::MEDICINE::Dermatology and venerology,clinical genetics, internal medicine::Clinical genetics
Research Subject Categories::MATHEMATICS::Applied mathematics
Handle http://genomebiology.com/2008/9/1/R13 (link to this page)
http://hdl.handle.net/2043/7400 (link to this page)

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