Low Salivary IgA Activity to Cell-surface Antigens of Mutans Streptococci Related to HLA-DRB1*04

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Low Salivary IgA Activity to Cell-surface Antigens of Mutans Streptococci Related to HLA-DRB1*04

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Publication Article, peer reviewed scientific
Title Low Salivary IgA Activity to Cell-surface Antigens of Mutans Streptococci Related to HLA-DRB1*04
Author(s) Wallengren, Marie-Louise ; Hamberg, Kristina ; Ericson, Dan ; Nordberg, J
Date 2005
English abstract
BACKGROUND/AIMS: Mutans streptococci are found in almost all individuals, though there are large differences in colonization levels between individuals. These differences are not readily explained, though several factors are believed to influence the colonization. One factor is the immune response to mutans streptococci, mainly provided by salivary immunoglobulin A (IgA). In a previous study, differences in salivary IgA reactions to oral streptococci were observed between human leukocyte antigen (HLA)-DR4-positive and DR4-negative indi-viduals. A lower salivary IgA activity to Streptococcus mutans in par-ticular was most pronounced for two DR4 subgroups, DRB1*0401 and *0404. The main purpose of this study was to further investigate, in a larger study group, the salivary IgA activity to antigens of three oral streptococci in relation to different HLA-DRB1*04 alleles. METHODS: Stimulated saliva was collected from 58 HLA-DRB1*04-positive individuals. Whole cell antigen extracts from S. mutans, Strep-tococcus sobrinus and Streptococcus parasanguis and the streptococ-cal antigen (SA) I/II were separated in SDS-PAGE, transblotted and detected with diluted saliva (Western blot), and analyzed in a com-puter program. All distinct immunoblot bands over 100 kDa were re-corded and compared in relation to DRB1*04. RESULTS: The im-munoblots revealed lower salivary IgA reactions to S. mutans, S. so-brinus and SA I/II, but not to S. parasanguis, for the DRB1*0401- and *0404-positive individuals compared to other DRB1*04 types. For the *0401 subgroup there was a significant association with a lower IgA response to S. mutans. CONCLUSION: The results confirm earlier ob-servations and may also support previous demonstrated association between colonization by mutans streptococci and the serologically de-fined HLA-DR4.
DOI http://dx.doi.org/10.1111/j.1399-302X.2004.00192.x (link to publisher's fulltext)
Publisher Blackwell Publishing
Host/Issue Oral Microbiology and Immunology;2
Volume 20
ISSN 0902-0055
Pages 73-81
Language eng (iso)
Subject(s) cell-surface antigen
HLA
oral streptococci
salivary IgA
Western blot
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/7864 (link to this page)

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