Bone response to free form-fabricated hydroxyapatite and zirconia scaffolds: a histological study in the human maxilla

DSpace Repository

Bone response to free form-fabricated hydroxyapatite and zirconia scaffolds: a histological study in the human maxilla

Show full item record

Files for download

Find Full text There are no files associated with this item..

Facebook

Simple item record

Publication Article, peer reviewed scientific
Title Bone response to free form-fabricated hydroxyapatite and zirconia scaffolds: a histological study in the human maxilla
Author(s) Malmström, Johan ; Slotte, Christer ; Adolfsson, Erik ; Norderyd, Ola ; Thomsen, Peter
Date 2009
English abstract
OBJECTIVES: Synthetic and biological materials are increasingly used to provide temporary or permanent scaffolds for bone regeneration. This study evaluated the effect of material chemistry and microporosity on bone ingrowth and osseointegration of zirconia (ZrO(2)) and hydroxyapatite (HA) scaffolds in the human maxilla. MATERIAL AND METHODS: Twelve patients subjected to dental implant placement were enrolled in the study. Scaffolds of ZrO(2) and HA were placed in the maxilla of each subject, using a randomization protocol. After 3 months of healing, biopsies were harvested comprising the scaffolds and surrounding bone tissue. The biopsies were processed for histological evaluation and morphometric analysis (bone ingrowth and bone-to-scaffold contact). RESULTS: Healing was uneventful in all cases. All scaffolds demonstrated a measurable bone response using light microscopy and scanning electron microscopy. Microporous HA scaffolds revealed four times larger bone ingrowth and seven times larger bone contact as compared with ZrO(2) scaffolds. CONCLUSION: The results show that chemistry and microporosity of HA promote bone ingrowth and bone contact of ceramic scaffolds in human maxilla.
DOI http://dx.doi.org/10.1111/j.1600-0501.2008.01595.x (link to publisher's fulltext)
Host/Issue Clinical Oral Implants Research;4
Volume 20
ISSN 0905-7161
Pages 379-85
Language eng (iso)
Subject(s) Medicine
Research Subject Categories::ODONTOLOGY::Periodontology
Research Subject Categories::ODONTOLOGY::Biomaterials
Research Subject Categories::ODONTOLOGY::Surgical research
Handle http://hdl.handle.net/2043/8121 (link to this page)

This item appears in the following Collection(s)

Show full item record

Search


Browse

My Account

Statistics