Activator protein-1 in carotid plaques is related to cerebrovascular symptoms and cholesteryl ester content

DSpace Repository

Activator protein-1 in carotid plaques is related to cerebrovascular symptoms and cholesteryl ester content

Show full item record

Files for download

Find Full text There are no files associated with this item.

Facebook

Simple item record

Publication Article, peer reviewed scientific
Title Activator protein-1 in carotid plaques is related to cerebrovascular symptoms and cholesteryl ester content
Author(s) Goncalves, Isabel ; Stollenwerk, Maria M ; Lindholm, Marie W ; Dias, Nuno ; Pedro, Luis M ; Fernandes e Fernandes, José ; Moses, Jonatan ; Nordin Fredrikson, Gunilla ; Nilsson, Jan ; Ares, Mikko PS
Date 2011
English abstract
Transcription factor activator protein-1 regulates genes involved in inflammation and repair. The aim of this study was to determine whether transcription factor activator protein-1 activity in carotid plaques is related to symptoms, lipid accumulation, or extracellular matrix composition. Methods: Twenty-eight atherosclerotic carotid plaques were removed by endarterectomy and divided into two groups based on the presence or absence of ipsilateral symptoms (b1 month ago). Activator protein-1 DNA binding activity was assessed, and subunit (c-Jun, JunD, JunB, c-Fos, FosB, Fra-1, Fra-2) protein levels analyzed by immunoblotting. Distribution of c-Jun in plaques was analyzed by immunohistochemistry. Results: Plaques associated with symptoms had increased activator protein-1 activity and increased expression of c-Jun and JunD, as compared to asymptomatic plaques. Fra-1 and Fra-2 were present in equal amounts in both groups, whereas JunB, FosB, and c-Fos were undetectable. Activator protein-1 activity correlated with cholesteryl ester and elastin in plaques and decreased with age. Activator protein-1 activity did not correlate with collagen, calcified tissue, or proteoglycan content. Conclusions: Activator protein-1 is increased in plaques associated with symptoms. The correlation between activator protein-1 and cholesteryl esters suggests that high activator protein-1 is a marker of plaque vulnerability. Activator protein-1 expression can also reflect the activation of repair processes.
DOI http://dx.doi.org/10.1016/j.carpath.2009.09.003 (link to publisher's fulltext)
Publisher Elsevier
Host/Issue Cardiovascular Pathology;1
Volume 20
ISSN 1054-8807
Pages 36-43
Language eng (iso)
Subject(s) AP-1
Atherosclerosis
Carotid artereis
Cerebrovascular disorders
Plaque
Medicine
Research Subject Categories::MEDICINE::Morphology, cell biology, pathology
Research Subject Categories::MEDICINE::Morphology, cell biology, pathology::Cell biology::Medical cell biology
Handle http://hdl.handle.net/2043/9093 (link to this page)

This item appears in the following Collection(s)

Show full item record

Search


Browse

My Account

Statistics