Effects of simvastatin on circulating autoantibodies to oxidized LDL antigens: relation with immune stimulation markers

DSpace Repository

Effects of simvastatin on circulating autoantibodies to oxidized LDL antigens: relation with immune stimulation markers

Show full item record

Files for download

Find Full text There are no files associated with this item.

Facebook

Simple item record

Publication Article, peer reviewed scientific
Title Effects of simvastatin on circulating autoantibodies to oxidized LDL antigens: relation with immune stimulation markers
Author(s) Goncalves, Isabel ; Cherfan, Pierre ; Söderberg, Ingrid ; Nordin Fredrikson, Gunilla ; Jonasson, Lena
Date 2009
English abstract
Statins exert a number of anti-inflammatory and immunomodulatory effects in vitro. However, the immunomodulatory effects in vivo are less clarified. In the present study, we investigated whether simvastatin treatment changed the levels of autoantibodies against specific oxidized LDL (oxLDL) antigens as well as their association with leukocyte activation markers. Eighty volunteers with mild-to-moderate hypercholesterolemia were randomized to either simvastatin 40 mg or placebo for 6 weeks. Autoantibodies against apo B peptide antigens, C-reactive protein (CRP) and interleukin (IL)-6 in plasma were determined by ELISA. Subsets of circulating B and T cells were studied by flow cytometry. Simvastatin significantly reduced CRP by 26%, whereas IL-6 remained unchanged. Levels of IgG against the apo B peptide P-240 (amino acids 3586-3605) increased by 16% (p = 0.03) in the simvastatin group whereas autoantibody levels to other apo B peptides did not change. At baseline and after 6 weeks, the P-240 IgG levels were significantly correlated with the number of CD57+CD28 - CD8+T cells but not to other lymphocyte subsets or inflammatory markers. The P-240 IgG levels after 6 weeks simvastatin therapy was strongly correlated to the relative increase in CD57+CD28 - CD8+T cells (p = 0.003). Simvastatin treatment induced an increase in autoantibodies against an oxLDL antigen. The effect was related to an expansion of a CD8+T cell subset and may involve an immunostimulation by simvastatin.
DOI http://dx.doi.org/10.1080/08916930802668602 (link to publisher's fulltext)
Host/Issue Autoimmunity;3
Volume 42
ISSN 0891-6934
Pages 203-208
Language eng (iso)
Subject(s) Medicine
Research Subject Categories::MEDICINE
Handle http://hdl.handle.net/2043/9183 (link to this page)

This item appears in the following Collection(s)

Show full item record

Search


Browse

My Account

Statistics