Associations between autoantibodies against apolipoprotein B-100 peptides and vascular complications in patients with type 2 diabetes

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Associations between autoantibodies against apolipoprotein B-100 peptides and vascular complications in patients with type 2 diabetes

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Publication Article, peer reviewed scientific
Title Associations between autoantibodies against apolipoprotein B-100 peptides and vascular complications in patients with type 2 diabetes
Author(s) Nordin Fredrikson, Gunilla ; Anand, Dhakshinamurthy Vijay ; Hopkins, David ; Corder, Roger ; Alm, Ragnar ; Bengtsson, Eva ; Shah, Prediman K ; Lahiri, Avijit ; Nilsson, Jan
Date 2009
English abstract
AIMS/HYPOTHESIS: Oxidation of LDL in the arterial extracellular matrix is a key event in the development of atherosclerosis and autoantibodies against oxidised LDL antigens reflect disease severity and the risk of developing acute cardiovascular events. Since type 2 diabetes is associated with increased oxidative stress, we tested the hypothesis that autoantibodies against oxidised LDL antigens are biomarkers for vascular complications in diabetes. METHODS: We studied 497 patients with type 2 diabetes without clinical signs of coronary heart disease. Oxidised LDL autoantibodies were determined by ELISA detecting IgG and IgM specific for native and malondialdehyde (MDA)-modified apolipoprotein B-100 peptides p45 and p210. The severity of coronary disease was assessed as the coronary artery calcium score. RESULTS: Patients affected by retinopathy had significantly higher levels of IgG against MDA-p45 and MDA-p210. In contrast, high levels of autoantibodies against the corresponding native peptides were associated with less coronary calcification and a lower risk of progression of coronary disease. CONCLUSIONS/INTERPRETATION: Our observations suggest that LDL oxidation is involved in the pathogenesis of diabetic retinopathy and that autoantibodies against apolipoprotein B peptides may act as biomarkers for both micro- and macrovascular complications in diabetes.
DOI http://dx.doi.org/10.1007/s00125-009-1377-9 (link to publisher's fulltext)
Host/Issue Diabetologia;7
Volume 52
ISSN 0012-186X
Pages 1426-1433
Language eng (iso)
Subject(s) Medicine
Research Subject Categories::MEDICINE
Handle http://hdl.handle.net/2043/9184 (link to this page)

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