Expression of PTEN and SHP1, investigated from tissue micro arrays in pediatric acute lymphoblastic leukaemia

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Expression of PTEN and SHP1, investigated from tissue micro arrays in pediatric acute lymphoblastic leukaemia

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Publication Article, peer reviewed scientific
Title Expression of PTEN and SHP1, investigated from tissue micro arrays in pediatric acute lymphoblastic leukaemia
Author(s) Gauffin, Fredrika ; Diffner, Eva ; Gustafsson, Bertil ; Nordgren, Ann ; Gjörloff Wingren, Anette ; Sander, Birgitta ; Persson Liao, Jenny ; Gustafsson, Britt
Date 2009
English abstract
PTEN and SHP1 are tumor suppressor genes involved in the regulation of cell cycle control and apoptosis. We have investigated the protein expression of PTEN and SHP 1, by immunohistochemistry in micro tissue arrays from bone marrow samples in children, diagnosed with acute lymphoblastic leukaemia and non-malignant controls. PTEN was over expressed in ALL samples, while SHP1 showed a low expression. PTEN showed a significant difference in expression compared to non-malignant controls. The role of PTEN and SHP1 are not well investigated in pediatric leukemias and could in future play a role as prognostic factors.
DOI http://dx.doi.org/10.1080/08880010802625530 (link to publisher's fulltext)
Publisher Informa Healthcare
Host/Issue Pediatric Hematology and Oncology;1
Volume 26
ISSN 1521-0669
Pages 48-56
Language eng (iso)
Subject(s) pediatric
leukemia
prognostic
biomarker
Medicine
Research Subject Categories::MEDICINE
Research Subject Categories::MEDICINE::Morphology, cell biology, pathology::Pathology::Molecular medicine
Handle http://hdl.handle.net/2043/9228 (link to this page)

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