Head to head comparisons of two modalities of perfusion adenosine stress echocardiography with simultaneous SPECT

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Head to head comparisons of two modalities of perfusion adenosine stress echocardiography with simultaneous SPECT

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Publication Article, peer reviewed scientific
Title Head to head comparisons of two modalities of perfusion adenosine stress echocardiography with simultaneous SPECT
Author(s) Gudmundsson, Petri ; Shahgaldi, Kambiz ; Winter, Reidar ; Dencker, Magnus ; Kitlinski, Mariusz ; Thorsson, Ola ; Ljunggren, Lennart ; Willenheimer, Ronnie
Date 2009
English abstract
Background: Real-time perfusion (RTP) contrast echocardiography can be used during adenosine stress echocardiography (ASE) to evaluate myocardial ischemia. We compared two different types of RTP power modulation techniques, angiomode (AM) and high-resolution grayscale (HR), with 99mTc-tetrofosmin single-photon emission computed tomography (SPECT) for the detection of myocardial ischemia. Methods: Patients with known or suspected coronary artery disease (CAD), admitted to SPECT, were prospectively invited to participate. Patients underwent RTP imaging (SONOS 5500) using AM and HR during Sonovue® infusion, before and throughout the adenosine stress, also used for SPECT. Analysis of myocardial perfusion and wall motion by RTP-ASE were done for AM and HR at different time points, blinded to one another and to SPECT. Each segment was attributed to one of the three main coronary vessel areas of interest. Results: In 50 patients, 150 coronary areas were analyzed by SPECT and RTP-ASE AM and HR. SPECT showed evidence of ischemia in 13 out of 50 patients. There was no significant difference between AM and HR in detecting ischemia (p = 0.08). The agreement for AM and HR, compared to SPECT, was 93% and 96%, with Kappa values of 0.67 and 0.75, respectively (p < 0.001). Conclusion: There was no significant difference between AM and HR in correctly detecting myocardial ischemia as judged by SPECT. This suggests that different types of RTP modalities give comparable data during RTP-ASE in patients with known or suspected CAD.
DOI http://dx.doi.org/10.1186/1476-7120-7-19 (link to publisher's fulltext)
Publisher BioMed Central Ltd
Host/Issue Cardiovascular Ultrasound
Volume 7
ISSN 1476-7120
Pages 19
Language eng (iso)
Subject(s) echocardiography
myocardial perfusion
contrast echocardiography
Medicine
Research Subject Categories::MEDICINE::Physiology and pharmacology::Physiology::Clinical physiology
Research Subject Categories::MEDICINE::Dermatology and venerology,clinical genetics, internal medicine::Internal medicine::Cardiology
Handle http://hdl.handle.net/2043/9233 (link to this page)

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