Effects of amphetamine on salivary secretion

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Effects of amphetamine on salivary secretion

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Publication Article, peer reviewed scientific
Title Effects of amphetamine on salivary secretion
Author(s) Götrick, Bengt ; Giglio, Daniel ; Tobin, Gunnar
Date 2009
English abstract
Amphetamine induces xerogenic effects, but its mechanism of action and xerogenic potency are unknown. In the current in vivo study on the rat parotid gland, the effects of amphetamine on reflex-evoked and acetylcholine-evoked salivation were examined in the absence and presence of adrenergic and dopaminergic antagonists. Under anaesthesia, amphetamine increased the secretion of salivary fluid and the amount of protein therein in response to acetylcholine. Phentolamine abolished the increase in salivary flow and had no effect on the salivary protein concentration, whereas propranolol only reduced the salivary protein concentration. Reflex activation of the secretion evoked a well-maintained level of secretion that was reduced by amphetamine [50% inhibitory dose (ID50) 1.9 ± 0.1 mg kg−1 intravenously); the salivary protein concentration was increased in the presence of amphetamine. Phentolamine and haloperidol reduced the amphetamine-inhibitory effect on the reflex-evoked fluid response, whereas propranolol had no effect on the fluid response. The xerogenic effect of amphetamine is mainly exerted by central mechanisms involving α-adrenoceptors, while, indirectly, amphetamine causes secretion of protein by inducing the release of noradrenaline from glandular nerve terminals.
DOI http://dx.doi.org/10.1111/j.1600-0722.2009.00629.x (link to publisher's fulltext)
Publisher Wiley InterScience
Host/Issue European journal of oral sceinces;3
Volume 117
ISSN 0909-8836
Pages 218-23
Language eng (iso)
Subject(s) α-adrenoceptor
amphetamine
central nervous system
parotid gland
rat
Medicine
Research Subject Categories::ODONTOLOGY::Physiology
Handle http://hdl.handle.net/2043/9915 (link to this page)

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