Altered glucose tolerance in women with deliberate self-harm

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Altered glucose tolerance in women with deliberate self-harm

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Publication Article, peer reviewed scientific
Title Altered glucose tolerance in women with deliberate self-harm
Author(s) Westling, Sofie ; Ahrén, Bo ; Sunnqvist, Charlotta ; Träskman-Bendz, Lil
Date 2009
English abstract
Disturbances in glucose metabolism are of importance for violent behaviour in men, but studies in women are lacking. We used the 5 h-oral glucose tolerance test (OGTT) in this study of 17 female psychiatric patients, selected for violent behaviour directed against themselves (deliberate self-harm) and 17 healthy controls matched for age and BMI. Following OGTT, patients had higher glucose levels at 30 min (p = 0.007) and increased glucagon area under the curve (p = 0.011). Since a co-morbid eating disorder might affect results, we as a post-hoc analysis subgrouped the patients and found that the increased glucagon levels only were present in patients with an eating disorder. In contrast, those without an eating disorder showed a significantly lower p-glucose nadir (p = 0.015) and unaltered glucagon levels compared to controls. There were no significant differences in insulin and C-peptide levels between patients and controls. We conclude that deliberate self-harm in women may be associated with alterations in carbohydrate metabolism in certain groups. Eating disorder is a confounding factor.
DOI http://dx.doi.org/10.1016/j.psyneuen.2008.12.015 (link to publisher's fulltext)
Publisher Science direct
Host/Issue Psychoneuroendocrinology;6
Volume 36
ISSN 0306-4530
Pages 878-883
Language eng (iso)
Subject(s) Glucose tolerance test
Deliberate self-harm
Violent
Insulin
Glucagon
Borderline personality disorder
Medicine
Research Subject Categories::MEDICINE::Psychiatry
Handle http://hdl.handle.net/2043/9978 (link to this page)

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